Compounding allows countless active ingredients to be incorporated into customized mouthwashes, gels, troches, etc. For example, to treat periodontal disease, antibiotics can be formulated as a mouthwash, or added to an oral adhesive paste or a plasticized gel that will maintain the contact between the tissue and medication for a prolonged period of time.
Metronidazole 25% in a lipogel-type base provides an efficient treatment of anaerobic infection when applied topically in the periodontal pockets.
J Int Acad Periodontol. 2000 Jul;2(3):64-70
Clinical evaluation of subgingival application of metronidazole 25%, and adjunctive therapy.
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Vojnosanit Pregl. 2005 Jul-Aug;62(7-8):565-8
Effects of topical application of metronidazole-containing mucoadhesive lipogel in periodontal pockets.
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Minerva Stomatol. 2000 Jan-Feb;49(1-2):59-67
[Topical treatment of peri-implantitis with metronidazole dental gel 25%. Clinical analysis and microbiological control]
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J Clin Periodontol. 1992 Oct;19(9 Pt 2):693-7
Systemic absorption of metronidazole after application of a metronidazole 25% dental gel.
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